autoantibodies against modified low density lipoprotein in patients with coronary heart disease and normal individuals
نویسندگان
چکیده
different classes of autoantibodies against two antigenic forms of modified low density lipoprotein (mod-ldl) were detected in 140 patients by indirect elisa method. investigated autoantibodes included total immunoglobulins (igt). immunoglobulin g (igg), and immunoglobulin m (igm) against oxidized ldl with copper ions (ox-ldl) and modified ldl with malondialdehyde (mal-ldl) (igt-o) igt against mal-ldl (igt-m), igg against ox-ldl (igg-o), igm against ox-ldl (igm-o), and igm against mal-ldl (igm-m) were significantly (p<0.05) higher in patient with coronary atherosclerosis than normal individuals, whereas titer of igg against mal-ldl (igg-m) didn’t show any significan difference between these groups. in this study, no correlation was found between autoantibody titers and severity of coronary artery stenosis. the results indicate that titers of these autoantibodies are dependent on an active atherogenic process.
منابع مشابه
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Autoantibodies against oxidized low density lipoprotein (oxLDL) have been proposed to be independent predictors of atherosclerotic vascular disease. Because the levels of autoantibodies against oxLDL and cardiolipin might be modified by the presentation and severity of coronary heart disease (CHD), we measured their levels in patients with different manifestations of CHD (n=415, mean age 61 yea...
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عنوان ژورنال:
acta medica iranicaجلد ۳۹، شماره ۴، صفحات ۱۹۱-۱۹۴
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